The study was conducted to evaluate the anti-stress potential of Tinospora Cordifolia (common name: Guduchi/Amruta) on solar radiation induced heat stress in sheep maintained under different managemental systems. The experiment was conducted in twelve Nellore Zodipi sheep with average body weight of 29�±0.56 Kg. Plant powder (@500 mg/Kg body weight) was orally administered daily for 30 days. The anti -stress activity of T.cordifolia was investigated by measuring changes in lipid peroxidation, glutathione level and superoxide dismutase activity in erythrocytes of sheep. In untreated sheep, there was a significant increase in the lipid peroxidation level and a significant reduction in the reduced glutathione and superoxide dismutase activity. In T. cordifolia supplemented animals (T2 and T3) the heat stress was significantly (P<0.05) reduced, which was indicated by change in the anti-oxidant profile. Oral administration of T.cordifolia plant powder modulated the lipid peroxidation, reduced glutathione and superoxide dismutase level of near normal in heat stressed sheep could be the most practical way to combat heat stress in animal by improving the anti oxidant status.
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